Residents and visitors alike have long known the secret, and now, word is out! Tri-Valley is one of California's premier wine destinations. Located just 40 miles southeast of San Francisco, Livermore/ Tri-Valley, California’s five-city region is home to forty wineries, world-class golf, creative culinary fare, and family friendly activities. Livermore/Tri-Valley, California is an authentic and unspoiled experience in which visitors can relax, refresh and recharge.